ABSTRACT
Background: The use of embryo cryopreservation excludes the possible detrimental effects of ovarian stimulation on the endometrium, and higher reproductive outcomes following this policy have been reported. Moreover, gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone [GnRH] antagonist cycles as a substitute for standard human chorionic gonadotropin trigger, minimizes the risk of ovarian hyperstimulation syndrome [OHSS] in fresh as well as frozen embryo transfer cycles [FET]
Objective: To compare the reproductive outcomes and risk of OHSS in fresh vs frozen embryo transfer in high responder patients, undergoing in vitro fertilization triggered with a bolus of GnRH agonist
Materials and Methods: In this randomized, multi-centre study, 121 women undergoing FET and 119 women undergoing fresh ET were investigated as regards clinical pregnancy as the primary outcome and the chemical pregnancy, live birth, OHSS development, and perinatal data as secondary outcomes
Results: There were no significant differences between FET and fresh groups regarding chemical [46.4% vs. 40.2%, p=0.352], clinical [35.8% vs. 38.3%, p=0.699], and ongoing [30.3% vs. 32.7%, p=0.700] pregnancy rates, also live birth [30.3% vs. 29.9%, p=0.953], perinatal outcomes, and OHSS development [35.6% vs. 42.9%, p=0.337]. No woman developed severe OHSS and no one required admission to hospital
Conclusion: Our findings suggest that GnRHa trigger followed by fresh transfer with modified luteal phase support in terms of a small human chorionic gonadotropin bolus is a good strategy to secure good live birth rates and a low risk of clinically relevant OHSS development in in vitro fertilization patients at risk of OHSS
ABSTRACT
This report explains briefly the minutes of a 1-day workshop entitled; "human embryonic stem cells [hESCs] and good manufacturing practice [GMP]" held by Stem Cell Biology Research Center based in Yazd Reproductive Sciences Institute at Shahid Sadoughi University of Medical Sciences, Yazd, Iran on 27[th] April 2017. In this workshop, in addition to the practical sessions, Prof. Harry D. Moore from Centre for Stem Cell Biology, University of Sheffield, UK presented the challenges and the importance of the biotechnology of clinical-grade human embryonic stem cells from first derivation to robust defined culture for therapeutic applications
ABSTRACT
This paper summarizes the proceedings of the stem cell session of the "7[th] Yazd International Congress and Student Award in Reproductive Medicine" held at Shahid Sadoughi University of Medical Sciences, Yazd, Iran, on 28-30 April 2017. Here, we collected the papers of the session entitled: "Stem Cells, Good manufacturing practice, and tissue engineering", that presented and discussed at this meeting by the international and national experts of the overlaps of the fields of stem cells and reproductive medicine, and the translation of these efforts towards practical application in regenerative medicine
ABSTRACT
Background: Despite of higher pregnancy rate after frozen embryo transfer [FET] which is accepted by the majority of researches, the safety of this method and its effect on neonatal outcome is still under debate
Objective: The aim of this study was to evaluate pregnancy and neonatal outcome of FET compare to fresh cycles
Materials and Methods: In this study,1134 patients using fresh ET and 285 women underwent FET were investigated regarding live birth as primary outcome and gestational age, birth weight, gender, multiple status, ectopic pregnancy, still birth and pregnancy loss as secondary outcomes
Results: Our results showed that there is no difference between FET and fresh cycles regarding live birth [65.6% vs. 70.4% respectively]. Ectopic pregnancy, still birth and abortion were similar in both groups. The mean gestational age was significantly lower among singletons in FET group compared to fresh cycles [p=0.047]. Prematurity was significantly elevated among singleton infants in FET group [19.6%] in comparison to neonates born after fresh ET [12.8%] [p=0.037]
Conclusion: It seems that there is no major difference regarding perinatal outcome between fresh and frozen embryo transfer. Although, live birth is slightly increased in fresh cycles and prematurity was significantly increased among singleton infants in FET group
ABSTRACT
This paper summarizes the proceedings of a 1 day national symposium entitled "Reproductive biology, stem cells biotechnology and regenerative medicine" held at Shahid Sadoughi University of Medical Sciences, Yazd, Iran on 3[rd] March 2016. Here, we collected the papers that presented and discussed at this meeting by specialists that currently researched about the overlaps of the fields of reproductive biology and stem cells and their applications in regenerative medicine
ABSTRACT
Background: Serum concentrations of antimullerian hormone [AMH] correlate with ovarian response during assisted reproduction treatment [ART] cycles
Objective: This retrospective study attempted to evaluate the selection of ovarian stimulation protocols based on serum AMH levels in patients and its impact on the results of ART
Materials and Methods: Based on AMH levels, the patients with tubal factor infertility were divided in three groups of normal, low and high AMH levels. Oocyte, good embryo number and pregnancy rate in each group were analyzed
Results: Using agonist and antagonist protocols, an increase in serum AMH led to higher number of oocytes and better quality embryos. At all low, normal and high AMH levels, the agonist protocol led to a more significant increase in the number of oocytes than the antagonist protocol [p<0.05]. The number of high quality embryos significantly increased by the agonist protocol than antagonist protocol in women with normal AMH levels of 1.3-2.6 ng/ml [p=0.00]. Moreover, the results for the number of high quality embryos at AMH >2.6 ng/ml was in favor of the antagonist protocol [p=0.00]. The results showed the lowest pregnancy rate at AMH <1.3 ng/ml. At AMH >2.6 ng/ml, there was a significant increase in pregnancy rate through the antagonist protocol [p=0.04]
Conclusion: Findings of this study suggested that the ART results are predictable, taking into account the AMH levels. The protocol specific to each patient can be used given the AMH level in each individual. This is because the results of each protocol depend on individual conditions